Curse of the Dead Gods is a roguelike and a dungeon crawler played from an isometric perspective. In the game, the player assumes control of an explorer who must navigate three different dungeons in search for money, power and eternal life. The dungeons are procedurally generated, and each of them are filled with deadly traps, hazards and hostile enemies. As the player progresses, they collect new weapons and unlock new upgrades. They also slowly earn Crystal Skulls and Jade Rings, which can be used to purchase permanent upgrades. These upgrades are automatically unlocked during subsequent runs and trials. The game features 10 different weapon classes. Different weapons have different attributes, and weapon effects can be combined. Players also need to manage their stamina during combat.
In addition to having a life meter, the game features a curse meter. The Curse meter increases as the player ventures into a new room, purchases items with a blood offering instead of gold, or fights enemies in the dark. Illuminating a room with braziers and torches can reduce darkness damage. Curses hinder the player’s abilities and present additional challenges and opportunities. They will be lifted as a reward for beating the in-game bosses.